Pitt Consortium to Research Pulmonary Fibrosis Treatments

Melanie Königshoff in a pink and white top

The schools of medicine at the University of Pittsburgh and Yale will lead a consortium to accelerate research into understanding and treatments of pulmonary fibrosis (PF). Pitt’s School of Medicine will receive a grant to develop and refine a new model to better understand the progression of PF and to identify possible therapies.

PF is a chronic, degenerative lung disease that causes lung tissue to become damaged and scarred, making it difficult for oxygen to enter the bloodstream. Each year, 40,000 Americans die from PF, yet very little is known about the mechanisms of the disease.

Melanie Königshoff, visiting professor of medicine at Pitt, is the lead investigator of the consortium. “I wanted to understand how diseased lungs can look so different from healthy lungs,” Königshoff said.

The COVID-19 pandemic has only increased the need for a deeper understanding of and more effective therapies for chronic lung conditions. As more people recover from COVID-19, therapies for living with long-term effects of lung diseases have become increasingly important.